Quantitative analysis of DNA binding affinity and dimerization properties of wild-type and mutant thyroid hormone receptor beta1.

doi:10.1089/thy.2000.10.11

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Article

Quantitative analysis of DNA binding affinity and dimerization properties of wild-type and mutant thyroid hormone receptor beta1.

Thyroid : official journal of the American Thyroid Association - 1 Jan 2000

Takeda T, Nagasawa T, Miyamoto T, Minemura K, Hashizume K, Degroot L J

Abstract excerpt

Thyroid hormone (triiodothyronine [T3]) actions are mediated through binding of thyroid hormone receptors (TRs) to specific DNA sequences (thyroid hormone response elements [TREs]) as monomers, homodimers, and heterodimers with thyroid hormone receptor auxiliary proteins (TRAPs). We quantitatively characterized dimerization of wild-type (WT) and mutant TRbetas by coimmunoprecipitation, and binding to DNA by...

Topics

Animals
Binding, Competitive
Cell Line
Chickens
DNA
Dimerization
Humans
Malate Dehydrogenase
Muramidase
Mutation
Rats

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Receptors, Retinoic Acid

Receptors, Thyroid Hormone

Reference Values

Response Elements

Retinoid X Receptors

Transcription Factors

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Open in PubMed

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PMID: 10691308
DOI: 10.1089/thy.2000.10.11

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