Article
Molecular and structural biology of thyroid hormone receptors.
Clinical and experimental pharmacology & physiology. Supplement - 1 Nov 1998
Apriletti J W, Ribeiro R C, Wagner R L, Feng W, Webb P, Kushner P J, West B L, Nilsson S, Scanlan T S, Fletterick R J, Baxter J D
Abstract excerpt
1. Thyroid hormone receptors (TR) are expressed from two separate genes (alpha and beta) and belong to the nuclear receptor superfamily, which also contains receptors for steroids, vitamins and prostaglandins. 2. Unliganded TR are bound to DNA thyroid hormone response elements (TRE) predominantly as homodimers, or as heterodimers with retinoid X-receptors (RXR), and are associated with a complex of proteins...
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