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Article

MDR1 genotype-dependent regulation of the aldosterone system in humans.

Pharmacogenetics and genomics - 1 Feb 2007

Zolk Oliver, Jacobi Johannes, Pahl Andreas, Fromm Martin F, Schmieder Roland E

Abstract excerpt

OBJECTIVE: Aldosterone plays a major role in the development of both hypertension and heart failure. As aldosterone is a substrate of the ABCB1 (P-glycoprotein) efflux transporter, whose expression and activity has been shown to be linked to the ABCB1 3435C-->T polymorphism, we tested the impact...

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Share to Aldosterone
Share to ATP Binding Cassette Transporter, Subfamily B, Member 1
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Kidney Function Tests

Share to Polymorphism, Single Nucleotide

Share to Renin-Angiotensin System

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Source

Identifiers

PMID: 17301693
DOI: 10.1097/01.fpc.0000239969.46594.d0

Genes

ABCB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-17301693-2026-09-04.1. Manifest publication-graph-cohort-2026-09-04.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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MDR1 genotype-dependent regulation of the aldosterone system in humans.PMID 17301693Read ↗

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