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Article

Modulation of aldosterone levels by -344 C/T CYP11B2 polymorphism and spironolactone use in resistant hypertension.

Journal of the American Society of Hypertension : JASH - 1 Mar 2014

Fontana Vanessa, de Faria Ana Paula Cabral, Barbaro Natália Ruggeri, Sabbatini Andréa Rodrigues, Modolo Rodrigo, Lacchini Riccardo, Moreno Heitor

Abstract excerpt

Interindividual variability in plasma aldosterone levels comprises environmental and genetic sources. Increased aldosterone levels have been associated with higher risk of hypertension and target-organ damage related to hypertension. Aldosterone excess and intravascular volume expansion are implicated in pathophysiology of resistant hypertension (RH). We sought to investigate whether -344 C/T polymorphism...

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PMID: 24388430
DOI: 10.1016/j.jash.2013.12.001

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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