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Article

MDR-1 C3435T polymorphism may affect blood pressure in resistant hypertensive patients independently of its effects on aldosterone release.

Journal of the renin-angiotensin-aldosterone system : JRAAS - 1 Jun 2014

Lacchini Riccardo, Figueiredo Valéria N, Demacq Caroline, Coeli-Lacchini Fernanda B, Martins Luís C, Yugar-Toledo Juan, Coca Antonio, Tanus-Santos Jose E, Moreno Heitor

Abstract excerpt

Aldosterone increases plasma volume and may be involved with resistant hypertension. P-glycoprotein is a transporter involved in the distribution and disposition of aldosterone, and is encoded by the MDR-1 gene. MDR-1 has functional polymorphisms that may affect P-glycoprotein expression. We hypothesized that the C(3435)T polymorphism in MDR-1 could be associated with resistant hypertension and with changes in...

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PMID: 23161145
DOI: 10.1177/1470320312466124

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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