Article
Phenotypic consequences of variation across the aldosterone synthase and 11-beta hydroxylase locus in a hypertensive cohort: data from the MRC BRIGHT Study.
Clinical endocrinology - 1 Dec 2007
Freel E M, Ingram M, Friel E C, Fraser R, Brown M, Samani N J, Caulfield M, Munroe P, Farrall M, Webster J, Clayton D, Dominiczak A F, Davies E, Connell J M C
Abstract excerpt
BACKGROUND: Aldosterone is an important cardiovascular hormone; 15% of hypertensive subjects have alteration in aldosterone regulation, defined by a raised ratio of aldosterone to renin (ARR). Studies of the aldosterone synthase gene (CYP11B2) have focused on a single nucleotide polymorphism in the 5'promoter region (-344 C/T). In normotensive subjects, the T allele associates with raised levels of the...
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