Article
Association of -344/T/C aldosterone synthase polymorphism (CYP11B2) with left ventricular structure and humoral parameters in young normotensive men.
Blood pressure - 1 Jan 2004
Heller Samuel, Linhart Ales, Jindra Antonín, Jáchymová Marie, Horký Karel, Peleska Jan, Hlubocká Zuzana, Umnerová Vera, Aschermann Michael
Abstract excerpt
BACKGROUND: Aldosterone plays an important role in development of left ventricular (LV) hypertrophy and myocardial fibrosis. We assessed the influence of the T-344C polymorphism of aldosterone synthase - the rate-limiting enzyme in aldosterone biosynthesis - on the structure of the left ventricle in young normotensive men. DESIGN AND METHODS: The population included 113 normotensive mid-European Caucasian men...
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