Article
Variants in ARHGEF11, a candidate gene for the linkage to type 2 diabetes on chromosome 1q, are nominally associated with insulin resistance and type 2 diabetes in Pima Indians.
Diabetes - 1 May 2007
Ma Lijun, Hanson Robert L, Que Lorem N, Cali Anna M G, Fu Mao, Mack Janel L, Infante Aniello M, Kobes Sayuko, Bogardus Clifton, Shuldiner Alan R, Baier Leslie J
Abstract excerpt
A prior genome-wide linkage scan in Pima Indians indicated a young-onset (aged <45 years) type 2 diabetes susceptibility locus on chromosome 1q21-q23. ARHGEF11, which encodes the Rho guanine nucleotide exchange factor 11, was analyzed as a positional candidate gene for this linkage because this protein may stimulate Rho-dependent signals, such as the insulin signaling cascade. The ARHGEF11 gene, and two adjacent...
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