Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genome-wide association study identifies novel loci association with fasting insulin and insulin resistance in African Americans.

Human molecular genetics - 15 Oct 2012

Chen Guanjie, Bentley Amy, Adeyemo Adebowale, Shriner Daniel, Zhou Jie, Doumatey Ayo, Huang Hanxia, Ramos Edward, Erdos Michael, Gerry Norman, Herbert Alan, Christman Michael, Rotimi Charles

Abstract excerpt

Insulin resistance (IR) is a key determinant of type 2 diabetes (T2D) and other metabolic disorders. This genome-wide association study (GWAS) was designed to shed light on the genetic basis of fasting insulin (FI) and IR in 927 non-diabetic African Americans. 5 396 838 single-nucleotide polymorphisms (SNPs) were tested for associations with FI or IR with adjustments for age, sex, body mass index, hypertension...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adiponectin
Share to Black or African American

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Body Mass Index

Share to Diabetes Mellitus, Type 2

Share to Fasting

Share to Insulin

Share to Insulin Resistance

Share to Transcriptional Elongation Factors

Source

Open in PubMed Open full text

Identifiers

PMID: 22791750
DOI: 10.1093/hmg/dds282
PMCID: PMC3459464

Genes

FTO
GCKR
IRS1
KLF14
PPARG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genome-wide association study identifies novel loci association with fasting insulin and insulin resistance in African Americans.PMID 22791750Read ↗

Exome Sequencing Identifies Genetic Variants Associated with Circulating Lipid Levels in Mexican Americans: The Insulin Resistance Atherosclerosis Family Study (IRASFS).Semantic proximity Read ↗

Whole genome sequence association analysis of fasting glucose and fasting insulin levels in diverse cohorts from the NHLBI TOPMed program.Semantic proximity Read ↗

Trans-ethnic Meta-analysis and Functional Annotation Illuminates the Genetic Architecture of Fasting Glucose and Insulin.Semantic proximity Read ↗

Genome-Wide Discovery Reveals Adipose-Specific and Systemic Regulators of Insulin ResistanceSemantic proximity Read ↗

A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance.Semantic proximity Read ↗

Genome-wide landscape establishes novel association signals for metabolic traits in the Arab population.Semantic proximity Read ↗

Genetic variation near IRS1 associates with reduced adiposity and an impaired metabolic profile.Semantic proximity Read ↗

Genome-wide detection of allele specific copy number variation associated with insulin resistance in African Americans from the HyperGEN study.Semantic proximity Read ↗

Genome-wide association meta-analysis identifies novel variants associated with fasting plasma glucose in East Asians.Semantic proximity Read ↗

Meta-analysis of genome-wide association studies in African Americans provides insights into the genetic architecture of type 2 diabetes.Semantic proximity Read ↗

Replication of genome-wide association studies (GWAS) loci for fasting plasma glucose in African-Americans.Semantic proximity Read ↗

Association analysis of variation in/near FTO, CDKAL1, SLC30A8, HHEX, EXT2, IGF2BP2, LOC387761, and CDKN2B with type 2 diabetes and related quantitative traits in Pima Indians.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.