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Article

R1467H variant in the rho guanine nucleotide exchange factor 11 (ARHGEF11) is associated with impaired glucose tolerance and type 2 diabetes in German Caucasians.

Journal of human genetics - 1 Jan 2008

Böttcher Yvonne, Schleinitz Dorit, Tönjes Anke, Blüher Matthias, Stumvoll Michael, Kovacs Peter

Abstract excerpt

The human rho guanine nucleotide exchange factor 11 (ARHGEF11) functions as an activator of rho GTPases and is supposed to influence insulin signalling. We investigated the effects of the previously reported R1467H variant in individual's susceptibility to type 2 diabetes (T2D) and impaired glucose tolerance (IGT) as well as related traits in a German Caucasian cohort. Our study replicated associations of the...

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Source

Identifiers

PMID: 18231709
DOI: 10.1007/s10038-008-0252-8

Genes

ARHGEF11

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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R1467H variant in the rho guanine nucleotide exchange factor 11 (ARHGEF11) is associated with impaired glucose tolerance and type 2 diabetes in German Caucasians.PMID 18231709Read ↗

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