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Article

A functional Tyr1306Cys variant in LARG is associated with increased insulin action in vivo.

Diabetes - 1 May 2006

Kovacs Peter, Stumvoll Michael, Bogardus Clifton, Hanson Robert L, Baier Leslie J

Abstract excerpt

Diminished insulin sensitivity is a characteristic feature of type 2 diabetes. Inhibition of insulin action, resulting in reduced skeletal muscle glucose uptake, is mediated in part through stimulation of RhoA activity. One regulator of RhoA activity is leukemia-associated Rho guanine nucleotide exchange factor (LARG). The LARG gene maps to a region on chromosome 11q23-24 that shows genetic linkage to BMI and...

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PMID: 16644711
DOI: 10.2337/db05-1331

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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