Article
An autosomal genomic scan for loci linked to prediabetic phenotypes in Pima Indians.
The Journal of clinical investigation - 15 Apr 1998
Pratley R E, Thompson D B, Prochazka M, Baier L, Mott D, Ravussin E, Sakul H, Ehm M G, Burns D K, Foroud T, Garvey W T, Hanson R L, Knowler W C, Bennett P H, Bogardus C
Abstract excerpt
Type 2 diabetes mellitus is a common chronic disease that is thought to have a substantial genetic basis. Identification of the genes responsible has been hampered by the complex nature of the syndrome. Abnormalities in insulin secretion and insulin action predict the development of type 2 diabetes and are, themselves, highly heritable traits. Since fewer genes may contribute to these precursors of type 2...
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