Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Evidence that Rho guanine nucleotide exchange factor 11 (ARHGEF11) on 1q21 is a type 2 diabetes susceptibility gene in the Old Order Amish.

Diabetes - 1 May 2007

Fu Mao, Sabra Mona M, Damcott Coleen, Pollin Toni I, Ma Lijun, Ott Sandra, Shelton John C, Shi Xiaolian, Reinhart Laurie, O'Connell Jeffrey, Mitchell Braxton D, Baier Leslie J, Shuldiner Alan R

Abstract excerpt

Rho guanine nucleotide exchange factor 11 (ARHGEF11), located on chromosome 1q21, is involved in G protein signaling and is a pathway known to play a role in both insulin secretion and action. We genotyped 52 single nucleotide polymorphims (SNPs) in ARHGEF11 and compared the genotype frequencies of subjects with type 2 diabetes (n = 145) or type 2 diabetes/impaired glucose tolerance (IGT) (n = 293) with those of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chromosome Mapping
Share to Chromosomes, Human, Pair 1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Diabetes Mellitus, Type 2

Share to Ethnicity

Share to Guanine Nucleotide Exchange Factors

Share to Polymorphism, Single Nucleotide

Share to Rho Guanine Nucleotide Exchange Factors

Share to United States

Source

Identifiers

PMID: 17369523
DOI: 10.2337/db06-1421

Genes

ARHGEF11

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Evidence that Rho guanine nucleotide exchange factor 11 (ARHGEF11) on 1q21 is a type 2 diabetes susceptibility gene in the Old Order Amish.PMID 17369523Read ↗

R1467H variant in the rho guanine nucleotide exchange factor 11 (ARHGEF11) is associated with impaired glucose tolerance and type 2 diabetes in German Caucasians.Semantic proximity Read ↗

Variants in ARHGEF11, a candidate gene for the linkage to type 2 diabetes on chromosome 1q, are nominally associated with insulin resistance and type 2 diabetes in Pima Indians.Semantic proximity Read ↗

Association of ARHGEF11 R1467H polymorphism with risk for type 2 diabetes mellitus and insulin resistance in Chinese population.Semantic proximity Read ↗

Human Rho guanine nucleotide exchange factor 11 gene is associated with schizophrenia in a Japanese population.Semantic proximity Read ↗

Identification of novel candidate genes for type 2 diabetes from a genome-wide association scan in the Old Order Amish: evidence for replication from diabetes-related quantitative traits and from independent populations.Semantic proximity Read ↗

Genetic variants in the leukemia-associated Rho guanine nucleotide exchange factor (ARHGEF12) gene are not associated with T2DM and related parameters in Caucasians (KORA study).Semantic proximity Read ↗

Common RASGRP1 Gene Variants That Confer Risk of Type 2 Diabetes.Semantic proximity Read ↗

Polymorphisms in the transcription factor 7-like 2 (TCF7L2) gene are associated with type 2 diabetes in the Amish: replication and evidence for a role in both insulin secretion and insulin resistance.Semantic proximity Read ↗

A genome-wide association study identifies GRK5 and RASGRP1 as type 2 diabetes loci in Chinese Hans.Semantic proximity Read ↗

Epigenetic alteration of Rho guanine nucleotide exchange Factor 11 (ARHGEF11) in cord blood samples in macrosomia exposed to intrauterine hyperglycemiaSemantic proximity Read ↗

PROX1 gene variant is associated with fasting glucose change after antihypertensive treatment.Semantic proximity Read ↗

Overexpression of alpha2A-adrenergic receptors contributes to type 2 diabetes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.