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Article

Association of ARHGEF11 R1467H polymorphism with risk for type 2 diabetes mellitus and insulin resistance in Chinese population.

Molecular biology reports - 1 Apr 2011

Liu Jing, Chen Xiaohui, Guo Qian, Ma Xiaoqin, Zhang Junqiang, Huang Xiaofeng, Zhang Xiaohui, Zhang Shulan

Abstract excerpt

The human Rho guanine nucleotide exchange factor 11 (ARHGEF11), located on chromosome 1q21, is an activator of Rho GTPases involved in G protein signaling pathway known to regulate insulin secretion and action. The aim of our study was to evaluate the relationship between the previously reported R1467H G/A variant in ARHGEF11 and risk of type 2 diabetes mellitus (T2DM) and insulin resistance as well as metabolic...

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Source

Identifiers

PMID: 21210224
DOI: 10.1007/s11033-010-0387-5

Genes

ARHGEF11

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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