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Article

Suppression of acute lymphoblastic leukemia by the human wild-type p53 gene.

Cancer research - 1 Jan 1992

Cheng J, Yee J K, Yeargin J, Friedmann T, Haas M

Abstract excerpt

Independent mutations in both alleles of the p53 tumor suppressor gene are a frequent finding in human T-cell acute lymphoblastic leukemia (T-ALL) cell lines and in the cells of some T-ALL patients in relapse. One major goal of studying the status of p53 (and other tumor suppressor genes) in human cancer is to facilitate the suppression of the tumorigenic phenotype through the restoration of the expression of the...

Topics

Animals
Feasibility Studies
Female
Gene Expression Regulation, Leukemic
Genes, p53
Humans
Leukemia-Lymphoma, Adult T-Cell
Mice
Mice, Nude
Phenotype
Suppression, Genetic
Tumor Cells, Cultured

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 1727382

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1727382-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Suppression of acute lymphoblastic leukemia by the human wild-type p53 gene.PMID 1727382Read ↗

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