Gain-of-function mutations of the p53 gene induce lymphohematopoietic metastatic potential and tissue invasiveness.

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Article

Gain-of-function mutations of the p53 gene induce lymphohematopoietic metastatic potential and tissue invasiveness.

The American journal of pathology - 1 Sept 1994

Hsiao M, Low J, Dorn E, Ku D, Pattengale P, Yeargin J, Haas M

Abstract excerpt

Leukemia cell infiltration and the induction of lethal hematopoietic disease in immune-deficient SCID mice transplanted with human T cell acute lymphoblastic T leukemia (T-ALL) cells occurred only when the cells possessed mutant p53 genes and lacked a wild-type allele or when T-ALL cells lacking p53 protein were infected with specific mutant p53 genes. A series of six mutant p53 genes were cloned from relapse...

Topics

Animals
Cell Division
Clone Cells
Female
Genes, p53
Genetic Vectors
Hematopoietic System
Humans
Leukemia-Lymphoma, Adult T-Cell
Lymphatic System
Mice

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice, SCID

Mutation

Neoplasm Invasiveness

Neoplasm Metastasis

Retroviridae

Transfection

Tumor Cells, Cultured

Source

Open in PubMed Open full text

Identifiers

PMID: 8080050
PMCID: PMC1890319

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-8080050-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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