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Article

Gain-of-function mutations of the p53 gene induce lymphohematopoietic metastatic potential and tissue invasiveness.

The American journal of pathology - 1 Sept 1994

Hsiao M, Low J, Dorn E, Ku D, Pattengale P, Yeargin J, Haas M

Abstract excerpt

Leukemia cell infiltration and the induction of lethal hematopoietic disease in immune-deficient SCID mice transplanted with human T cell acute lymphoblastic T leukemia (T-ALL) cells occurred only when the cells possessed mutant p53 genes and lacked a wild-type allele or when T-ALL cells lacking p53 protein were infected with specific mutant p53 genes. A series of six mutant p53 genes were cloned from relapse...

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Identifiers

PMID: 8080050
PMCID: PMC1890319

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Gain-of-function mutations of the p53 gene induce lymphohematopoietic metastatic potential and tissue invasiveness.PMID 8080050Read ↗

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