Article
Genetic mechanisms of tumor suppression by the human p53 gene.
Science (New York, N.Y.) - 14 Dec 1990
Chen P L, Chen Y M, Bookstein R, Lee W H
Abstract excerpt
Mutations of the gene encoding p53, a 53-kilodalton cellular protein, are found frequently in human tumor cells, suggesting a crucial role for this gene in human oncogenesis. To model the stepwise mutation or loss of both p53 alleles during tumorigenesis, a human osteosarcoma cell line, Saos-2, w...
Topics
- Alleles
- Base Sequence
- Cinnamates
- Cloning, Molecular
- DNA
- Drug Resistance
- Genes, p53
- Genetic Vectors
- Humans
- Hygromycin B
- Molecular Sequence Data
- Moloney murine leukemia virus
- Mutation
- Neomycin
- Osteosarcoma
- Plasmids
- Transfection
- Tumor Cells, Cultured