Role of the p53 tumor suppressor gene in the pathogenesis and in the suppression of acute lymphoblastic T-cell leukemia.

Abstract excerpt

The tumor suppressor gene p53 has been shown to be mutated in 50% of acute lymphoblastic T-cell-leukemia (T-ALL) cell lines, all of which were established from T-ALL cases in relapse. In these lines both alleles of the p53 gene were independently affected by point mutation. In contrast, in human solid tumors possessing a mutated p53 allele, the second wild-type p53 suppressor allele is often lost by deletion...

Topics

• Animals
• Chromosome Deletion
• Codon
• Genes, p53
• Genetic Therapy
• Heterozygote
• Homozygote
• Humans
• Leukemia-Lymphoma, Adult T-Cell
• Mice
• Mice, Nude
• Mutation