P53 mutation in acute T cell lymphoblastic leukemia is of somatic origin and is stable during establishment of T cell acute lymphoblastic leukemia cell lines.

doi:10.1172/JCI116435

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Article

P53 mutation in acute T cell lymphoblastic leukemia is of somatic origin and is stable during establishment of T cell acute lymphoblastic leukemia cell lines.

The Journal of clinical investigation - 1 May 1993

Yeargin J, Cheng J, Yu A L, Gjerset R, Bogart M, Haas M

Abstract excerpt

Samples donated by patients with T cell acute lymphoblastic leukemia (T-ALL) were screened for mutations of the p53 tumor suppressor gene. Peripheral blood cells of T-ALL relapse patient H.A. were found to possess a heterozygous point mutation at codon 175 of the p53 gene. To determine whether th...

Topics

Adult
Antigens, CD
Antineoplastic Combined Chemotherapy Protocols
Base Sequence
Bone Marrow
Chromosome Aberrations
Chromosome Disorders
DNA
Female
Genes, p53
HLA-DR Antigens
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Karyotyping

Leukemia-Lymphoma, Adult T-Cell

Molecular Sequence Data

Mutation

Oligodeoxyribonucleotides

Polymerase Chain Reaction

Source

Open in PubMed Open full text

Identifiers

PMID: 8486778
DOI: 10.1172/JCI116435
PMCID: PMC288211

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8486778-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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