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Frequent Mutations in the p53 Tumor Suppressor Gene in Human Leukemia T-Cell Lines

1 Oct 1990

Abstract excerpt

Human T-cell leukemia and T-cell acute lymphoblastic leukemia cell lines were studied for alterations in the p53 tumor suppressor gene. Southern blot analysis of 10 leukemic T-cell lines revealed no gross genomic deletions or rearrangements. Reverse transcription-polymerase chain reaction analysis of p53 mRNA indicated that all 10 lines produced p53 mRNA of normal size. By direct sequencing of polymerase chain...

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PMID: 2144611
DOI: 10.1128/mcb.10.10.5502-5509.1990

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