Article
Expression of wild-type p53 in human A673 cells suppresses tumorigenicity but not growth rate.
Oncogene - 1 Oct 1991
Chen Y M, Chen P L, Arnaiz N, Goodrich D, Lee W H
Abstract excerpt
The p53 gene has been found to be mutated in many different kinds of human cancers. In a previous study, expression of exogenous wild-type p53 in human osteosarcoma cells by retrovirus-mediated gene transfer resulted in marked enlargement of cell size, reduced growth rate in culture and loss of tumorigenicity in nude mice. Here we examine the effects of expression of wild-type or mutated p53 on human peripheral...
Topics
- Amino Acid Sequence
- Cell Division
- Gene Expression Regulation, Neoplastic
- Genes, p53
- Humans
- Molecular Sequence Data
- Mutation
- Neuroectodermal Tumors, Primitive, Peripheral
- Polymerase Chain Reaction
- Transfection
- Tumor Cells, Cultured