Nonhereditary p53 mutations in T-cell acute lymphoblastic leukemia are associated with the relapse phase.

Abstract excerpt

We have previously reported that greater than 60% of human leukemic T-cell lines possess mutations in the p53 tumor suppressor gene. To determine whether T-cell acute lymphoblastic leukemia (T-ALL) patient samples possess p53 mutations, we screened peripheral blood-and bone marrow-derived leukemi...

Topics

• Base Sequence
• Chromosome Deletion
• Genes, p53
• Humans
• Leukemia-Lymphoma, Adult T-Cell
• Molecular Sequence Data
• Mutation
• Recurrence