Article

Frequent mutations in the p53 tumor suppressor gene in human leukemia T-cell lines.

1990-10-01

Abstract excerpt

Human T-cell leukemia and T-cell acute lymphoblastic leukemia cell lines were studied for alterations in the p53 tumor suppressor gene. Southern blot analysis of 10 leukemic T-cell lines revealed no gross genomic deletions or rearrangements. Reverse transcription-polymerase chain reaction analysis of p53 mRNA indicated that all 10 lines produced p53 mRNA of normal size. By direct sequencing of polymerase chain rea...

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Literature Corpus work: 8b2fb22a-1ba7-50e0-88f2-5007b73d2d3f
DOI: 10.1128/mcb.10.10.5502

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