Article
IL-3 can not replace GM-CSF in inducing human monocytes to differentiate into Langerhans cells.
International journal of oncology - 1 Mar 2007
Shibasaki Tetsunori, Katayama Naoyuki, Ohishi Kohshi, Fujieda Atsushi, Monma Fumihiko, Nishi Kazuhiro, Masuya Masahiro, Shiku Hiroshi
Abstract excerpt
Receptors for granulocyte-macrophage colony-stimulating factor (GM-CSF) and interleukin-3 (IL-3) share a common beta subunit. We recently reported that GM-CSF acts in concert with transforming growth factor-beta1 (TGF-beta1) and Notch ligand Delta-1 (Delta-1) to promote the differentiation of human blood monocytes into Langerhans cells. In the present study, we examined whether IL-3, in place of GM-CSF, can...
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