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Article

GM-CSF promotes differentiation of a precursor cell of monocytes and Langerhans-type dendritic cells from CD34+ haemopoietic progenitor cells.

British journal of haematology - 1 May 1998

Herbst B, Köhler G, Mackensen A, Veelken H, Lindemann A

Abstract excerpt

Epithelia-associated dendritic cells (DC) including Langerhans cells in the skin (LC) are precursors of lymph node located interdigitating DC (iDC). CD1a+ LC are known to be derived from CD34+ haemopoietic progenitor cells (HPC); however, cells of an intermediate differentiation state that are CD34- and CD1a- have not been identified. Monitoring the differentiation pathway of HPC in the presence of GM-CSF+IL-4,...

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Identifiers

PMID: 9609515
DOI: 10.1046/j.1365-2141.1998.00685.x

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