Article
Notch-Mediated Generation of Monocyte-Derived Langerhans Cells: Phenotype and Function.
The Journal of investigative dermatology - 1 Jan 2021
Bellmann Lydia, Zelle-Rieser Claudia, Milne Paul, Resteu Anastasia, Tripp Christoph H, Hermann-Kleiter Natascha, Zaderer Viktoria, Wilflingseder Doris, Hörtnagl Paul, Theochari Maria, Schulze Jessica, Rentzsch Mareike, Del Frari Barbara, Collin Matthew, Rademacher Christoph, Romani Nikolaus, Stoitzner Patrizia
Abstract excerpt
Langerhans cells (LCs) in the skin are a first line of defense against pathogens but also play an essential role in skin homeostasis. Their exclusive expression of the C-type lectin receptor Langerin makes them prominent candidates for immunotherapy. For vaccine testing, an easily accessible cell platform would be desirable as an alternative to the time-consuming purification of LCs from human skin. Here, we...
Topics
- Cell Differentiation
- Cells, Cultured
- Dendritic Cells
- Humans
- Langerhans Cells
- Lymphocyte Activation
- Monocytes
- Phenotype
- Skin