Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Interleukin 15 skews monocyte differentiation into dendritic cells with features of Langerhans cells.

The Journal of experimental medicine - 1 Oct 2001

Mohamadzadeh M, Berard F, Essert G, Chalouni C, Pulendran B, Davoust J, Bridges G, Palucka A K, Banchereau J

Abstract excerpt

Langerhans cells (LCs) represent a subset of immature dendritic cells (DCs) specifically localized in the epidermis and other mucosal epithelia. As surrounding keratinocytes can produce interleukin (IL)-15, a cytokine that utilizes IL-2Rgamma chain, we analyzed whether IL-15 could skew monocyte differentiation into LCs. Monocytes cultured for 6 d with granulocyte/macrophage colony-stimulating factor (GM-CSF) and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antigen Presentation
Share to Epidermal Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Epidermis

Share to Granulocyte-Macrophage Colony-Stimulating Factor

Share to Interleukin-15

Share to Langerhans Cells

Share to Lymphocyte Culture Test, Mixed

Share to Monocytes

Source

Open in PubMed Open full text

Identifiers

PMID: 11581322
DOI: 10.1084/jem.194.7.1013
PMCID: PMC2193478

Genes

CCL20
MIP
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Interleukin 15 skews monocyte differentiation into dendritic cells with features of Langerhans cells.PMID 11581322Read ↗

IL‐15‐induced human DC efficiently prime melanoma‐specific naive CD8<sup>+</sup> T cells to differentiate into CTLSemantic proximity Read ↗

Short-term cultured, interleukin-15 differentiated dendritic cells have potent immunostimulatory properties.Semantic proximity Read ↗

Interleukin-15 Constrains Mucosal T Helper 17 Cell Generation: Influence of Mononuclear Phagocytes.Semantic proximity Read ↗

A novel role for Notch ligand Delta-1 as a regulator of human Langerhans cell development from blood monocytes.Semantic proximity Read ↗

Notch-Mediated Generation of Monocyte-Derived Langerhans Cells: Phenotype and Function.Semantic proximity Read ↗

Mixed Langerhans cell and interstitial/dermal dendritic cell subsets emanating from monocytes in Th2-mediated inflammatory conditions respond differently to proinflammatory stimuli.Semantic proximity Read ↗

Transpresentation of interleukin-15 by IL-15/IL-15Rα mRNA-engineered human dendritic cells boosts antitumoral natural killer cell activity.Semantic proximity Read ↗

The maturation-dependent production of interleukin-16 is impaired in monocyte-derived dendritic cells from atopic dermatitis patients but is restored by inflammatory cytokines TNF-alpha and IL-1beta.Semantic proximity Read ↗

Human cytomegalovirus-derived protein UL18 alters the phenotype and function of monocyte-derived dendritic cells.Semantic proximity Read ↗

IL-3 can not replace GM-CSF in inducing human monocytes to differentiate into Langerhans cells.Semantic proximity Read ↗

Trans-presentation of IL-15 modulates STAT5 activation and Bcl-6 expression in TH1 cellsSemantic proximity Read ↗

Expression of interleukin-15 and interleukin-15Rα in monocytes of HIV type 1-infected patients with different courses of disease progression.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.