Article
Development of a Langerhans cell phenotype from peripheral blood monocytes.
Immunology letters - 1 Feb 1992
Rossi G, Heveker N, Thiele B, Gelderblom H, Steinbach F
Abstract excerpt
Epidermal Langerhans cells (ELC) are definitively primed to differentiate into dendritic cells (DC). It is unknown at what stage of monocyte development this priming occurs. In a culture system characterized by low paracrine stimulation, i.e. Iscove's modified Dulbecco medium (IMDM) with 2% FCS, we tested the ability of peripheral blood monocytes to turn to the route of the LC-DC lineage. In this system monocytes...
Topics
- Antigens, CD
- Antigens, CD1
- Antigens, Differentiation, Myelomonocytic
- Cell Differentiation
- Culture Media
- HLA-DR Antigens
- Humans
- In Vitro Techniques
- Langerhans Cells
- Lectins, C-Type
- Lipopolysaccharide Receptors