Article
Down-regulation of Toll-like receptor expression in monocyte-derived Langerhans cell-like cells: implications of low-responsiveness to bacterial components in the epidermal Langerhans cells.
Biochemical and biophysical research communications - 4 Jul 2003
Takeuchi Junko, Watari Eiji, Shinya Eiji, Norose Yoshihiko, Matsumoto Misako, Seya Tsukasa, Sugita Masahiko, Kawana Seiji, Takahashi Hidemi
Abstract excerpt
In the skin, there are unique dendritic cells called Langerhans cells, however, it remains unclear why this particular type of dendritic cell resides in the epidermis. Langerhans cell-like dendritic cells (LCs) can be generated from CD14(+) monocytes in the presence of GM-CSF, IL-4, and TGF-beta1...
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