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Article

A novel role for Notch ligand Delta-1 as a regulator of human Langerhans cell development from blood monocytes.

Journal of leukocyte biology - 1 Oct 2005

Hoshino Natsuki, Katayama Naoyuki, Shibasaki Tetsunori, Ohishi Kohshi, Nishioka Junji, Masuya Masahiro, Miyahara Yoshihiro, Hayashida Masahiko, Shimomura Daiki, Kato Takuma, Nakatani Kaname, Nishii Kazuhiro, Kuribayashi Kagemasa, Nobori Tsutomu, Shiku Hiroshi

Abstract excerpt

Human Langerhans cells (LCs) are of hematopoietic origin, but cytokine regulation of their development is not fully understood. Notch ligand Delta-1 is expressed in a proportion of the skin. Granulocyte-macrophage colony-stimulating factor (GM-CSF) and transforming growth factor-beta1 (TGF-beta1) are also secreted in the skin. We report here that Delta-1, in concert with GM-CSF and TGF-beta1, induces the...

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PMID: 16037408
DOI: 10.1189/jlb.1204746

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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