Article
Induction of langerin+ Langerhans cell-like cells expressing reduced TLR3 from CD34+ cord blood cells stimulated with GM-CSF, TGF-β1, and TNF-α.
Biomedical research (Tokyo, Japan) - 1 Jan 2016
Azuma Hideko, Watanabe Eri, Otsuka Yohei, Negishi Yasuyuki, Ohkura Sadayuki, Shinya Eiji, Takahashi Hidemi
Abstract excerpt
Langerhans cells (LCs), a subset of dendritic cells (DCs), reside in body surface presenting antigens from various pathogens and activate immune system after migrating to vicinal lymph nodes. We recently demonstrated that the E-cadherin interaction allowed peripheral blood (PB) CD14+ cells to differentiate into LC-like cells that closely resemble primary LCs. Here, with a combination of GM-CSF, TGF-β, and TNF-α,...
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