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Article

TGFBR2 mutation is correlated with CpG island methylator phenotype in microsatellite instability-high colorectal cancer.

Human pathology - 1 Apr 2007

Ogino Shuji, Kawasaki Takako, Ogawa Akiyo, Kirkner Gregory J, Loda Massimo, Fuchs Charles S

Abstract excerpt

The transforming growth factor-beta receptor type 2 gene (TGFBR2) is mutated in most microsatellite instability-high (MSI-H) colorectal cancers. Promoter methylation of RUNX3 (runt-related transcription factor 3; encoding a transcription factor downstream of the TGF-beta pathway) is observed in c...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 17270239
DOI: 10.1016/j.humpath.2006.10.005

Genes

RUNX3
TGFBR2
BRAF
KRAS
CRABP1
IGF2
MLH1
NEUROG1
SOCS1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17270239-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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