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Article

IGFBP3 promoter methylation in colorectal cancer: relationship with microsatellite instability, CpG island methylator phenotype, and p53.

Neoplasia (New York, N.Y.) - 1 Dec 2007

Kawasaki Takako, Nosho Katsuhiko, Ohnishi Mutsuko, Suemoto Yuko, Kirkner Gregory J, Fuchs Charles S, Ogino Shuji

Abstract excerpt

Insulin-like growth factor binding protein 3 (IGFBP3), which is induced by wild-type p53, regulates IGF and interacts with the TGF-beta pathway. IGFBP3 promoter methylation may occur in colorectal cancer with or without the CpG island methylator phenotype (CIMP), which is associated with microsatellite instability (MSI) and TGFBR2 mutation. We examined the relationship between IGFBP3 methylation, p53 expression,...

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Topics

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Share to Chromosomes, Human, Pair 18
Share to CpG Islands

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA, Neoplasm

Share to Genes, p53

Share to Insulin-Like Growth Factor Binding Protein 3

Share to Insulin-Like Growth Factor Binding Proteins

Share to Loss of Heterozygosity

Share to Microsatellite Instability

Source

Open in PubMed Open full text

Identifiers

PMID: 18084616
DOI: 10.1593/neo.07760
PMCID: PMC2134905

Genes

IGFBP3
TGFBR2
CRABP1
IGF2
MLH1
NEUROG1
RUNX3
SOCS1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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