Article
The initial response of CD4+ IL-4-producing cells.
International immunology - 1 Mar 2007
Xin Junping, Ohmori Keitaro, Nishida Jun, Zhu Yuechun, Huang Hua
Abstract excerpt
Naive CD4(+) T cells were reported to produce small amounts of IL-4 in vitro, which are implicated to be sufficient to initiate T(h)2 response in vivo. However, IL-4-producing naive CD4(+) T cells are difficult to study in vivo because they are present in low numbers shortly after the first antigen exposure. Here, we used IL-4/green fluorescence protein (GFP) reporter mice (G4 mice) to track the initial response...
Topics
- Animals
- Antigens
- CD4-Positive T-Lymphocytes
- Cell Separation
- Flow Cytometry
- GATA3 Transcription Factor
- Gene Expression
- Genes, Reporter
- Green Fluorescent Proteins
- Immunization
- Interleukin-13