Article
Regulation of expression of IL-4 alleles: analysis using a chimeric GFP/IL-4 gene.
Immunity - 1 Jan 2001
Hu-Li J, Pannetier C, Guo L, Löhning M, Gu H, Watson C, Assenmacher M, Radbruch A, Paul W E
Abstract excerpt
CD4 cells from mice heterozygous for an IL-4 and a GFP/IL-4 gene frequently express a single allele. Analysis of IL-4 or GFP production by cells from recently primed Th2 cells indicates that essentially all are competent to transcribe either allele but have a low probability of doing so. By contrast, long-term Th2 clones show distinct and heritable ratios in the proportion of cells that express IL-4 or GFP. We...
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