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Article

<i>In vivo</i> studies fail to reveal a role for IL-4 or STAT6 signaling in Th2 lymphocyte differentiation

21 Aug 2008

Abstract excerpt

The expression of interleukin-4 (IL-4) is viewed as the hallmark of a Th2 lymphocyte, whereas the subsequent action of IL-4 and IL-13, mediated through the STAT6 signaling pathway, is seen as a prerequisite for the full development of Th2 immune responses to parasites and allergens. G4 mice, whose IL-4 gene locus contains the fluorescent reporter eGFP, were used to quantify the number of Th2 cells that develop...

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PMID: 18719110
DOI: 10.1073/pnas.0806372105

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