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Article

Disrupting Il13 impairs production of IL-4 specified by the linked allele.

Nature immunology - 1 May 2001

Guo L, Hu-Li J, Zhu J, Pannetier C, Watson C, McKenzie G J, McKenzie A N, Paul W E

Abstract excerpt

Interleukin 13-deficient (IL-13-/-) mice express a defect in priming for IL-4 production that is not corrected by adding IL-13 to the priming culture. This is partly accounted for by the consumption of IL-4 without endogenous replacement during culture of IL-13-/- CD4+ T cells. We examined cells from mice in which disrupted Il13 was linked to wild-type Il4 on one chromosome and wild-type Il13 was linked to a...

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PMID: 11323701
DOI: 10.1038/87778

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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