Article
IL-4 induces differentiation and expansion of Th2 cytokine-producing eosinophils.
Journal of immunology (Baltimore, Md. : 1950) - 15 Feb 2004
Chen Luqiu, Grabowski Kristy A, Xin Jun-Ping, Coleman John, Huang Zan, Espiritu Baltazar, Alkan Serhan, Xie H Bill, Zhu Yuechun, White Fletcher A, Clancy John, Huang Hua
Abstract excerpt
Innate effector cells that produce Th2-type cytokines are critical in Th2 cell-mediated immune responses. However, it is not known how these cells acquire the ability to produce Th2 cytokines. IL-4 is a potent inducer that directs differentiation of naive CD4(+) T cells into CD4(+) Th2 effector cells. To determine whether IL-4 can induce differentiation and expansion of Th2 cytokine-producing innate cells, we...
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