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Article

New TCR transgenic model for tracking allospecific CD4 T-cell activation and tolerance in vivo.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons - 1 Oct 2003

Sandner Sigrid E, Salama Alan D, Houser Stuart L, Palmer Ed, Turka Laurence A, Sayegh Mohamed H

Abstract excerpt

We have developed an adoptive transfer model system to visualize the dynamics of alloantigen-specific CD4+ T-cell activation in vivo. Using TCR-transgenic (tg) mice reactive to I-Ab(m12), we studied the clonal expansion and differentiation of alloreactive T cells by tracking the fate of adoptively transferred TCR-tg CD4+ T cells in syngeneic mice transplanted with skin grafts expressing I-Ab(m12). Following...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 14510697
DOI: 10.1046/j.1600-6143.2003.00220.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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