Article
In differentiated CD4+ T cells, interleukin 4 production is cytokine-autonomous, whereas interferon gamma production is cytokine-dependent.
Proceedings of the National Academy of Sciences of the United States of America - 1 Apr 1997
Hu-Li J, Huang H, Ryan J, Paul W E
Abstract excerpt
CD4+ T cells from T cell receptor transgenic mice that have been vigorously primed to be interleukin (IL)-4 producers (T(H2) cells) are capable of producing IL-4 even if restimulated in the absence of IL-4 and in the presence of IL-12. T cells vigorously primed in the absence of IL-4 (T(H1) cells) fail to produce IL-4 even if restimulated under conditions that would cause a naive T cell to produce IL-4. In...
Topics
- Animals
- Cell Differentiation
- Interferon-gamma
- Interleukin-12
- Interleukin-4
- Mice
- Phenotype
- Th1 Cells