Article
Response of naive antigen-specific CD4+ T cells in vitro: characteristics and antigen-presenting cell requirements.
The Journal of experimental medicine - 1 Nov 1992
Croft M, Duncan D D, Swain S L
Abstract excerpt
Because of the low frequency of T cells for any particular soluble protein antigen in unprimed animals, the requirements for naive T cell responses in specific antigens have not been clearly delineated and they have been difficult to study in vitro. We have taken advantage of mice transgenic for...
Topics
- Animals
- Antigen-Presenting Cells
- Antigens
- CD4-Positive T-Lymphocytes
- Cell Line
- Dendritic Cells
- Interleukin-2
- Leukocyte Common Antigens
- Lymphocyte Activation
- Male
- Mice
- Mice, Inbred C57BL
- Phenotype
- Receptors, Lymphocyte Homing