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Article

Response of naive antigen-specific CD4+ T cells in vitro: characteristics and antigen-presenting cell requirements.

The Journal of experimental medicine - 1 Nov 1992

Croft M, Duncan D D, Swain S L

Abstract excerpt

Because of the low frequency of T cells for any particular soluble protein antigen in unprimed animals, the requirements for naive T cell responses in specific antigens have not been clearly delineated and they have been difficult to study in vitro. We have taken advantage of mice transgenic for the V beta 3/V alpha 11 T cell receptor (TCR), which can recognize a peptide of cytochrome c presented by IEk. 85-90%...

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Identifiers

PMID: 1357074
DOI: 10.1084/jem.176.5.1431
PMCID: PMC2119425

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