Article
[Gene expression of tumor cells both in vitro and in vivo enhanced by integrin-targeting adenovirus vector].
Yao xue xue bao = Acta pharmaceutica Sinica - 1 Nov 2006
Gao Jian-qing, Chen Hai-liang, Nakagawa Shinsaku, Mizuguchi Hiroyuki, Liang Wen-quan
Abstract excerpt
AIM: To construct an efficient recombinant viral vector for gene therapy. METHODS: First-generation adenovirus (Ad) vector was modified with the RGD peptide inserted into the fiber. Both in vitro and in vivo experiments of gene expression in different tumor cells with conventional and recombinant vectors were conducted. RT-PCR was used for detecting the expression of coxackievirus and adenovirus receptor and...
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