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Modified adenoviruses for cancer gene therapy

15 Mar 2004

Abstract excerpt

Adenoviral gene therapy is an exciting novel approach for treating cancers resistant to currently available therapies. However, currently there is little evidence supporting significant clinical benefits with replication-incompetent adenoviruses. Recent data suggest that expression of the primary receptor, the coxsackie-adenovirus receptor (CAR), may be highly variable on tumor cells, resulting in resistance to...

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PMID: 15122578
DOI: 10.1002/ijc.20129

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