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Chapter four--Design of improved oncolytic adenoviruses.

Advances in cancer research - 1 Jan 2012

Alemany Ramon

Abstract excerpt

During the last decade adenovirus has lost its appeal in gene therapy due to a high immunogenicity that leads to a transient gene expression. However, adenovirus has gained attention as replication-competent vector to treat cancer. Designed for virotherapy, adenovirus has been successfully modified to replicate selectively in tumor cells. After the initial clinical trials with tumor-selective adenoviruses, it has...

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PMID: 23021243
DOI: 10.1016/B978-0-12-398342-8.00004-5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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