Article
Fiber-mutant technique can augment gene transduction efficacy and anti-tumor effects against established murine melanoma by cytokine-gene therapy using adenovirus vectors.
Cancer letters - 8 Mar 2002
Okada Yuka, Okada Naoki, Nakagawa Shinsaku, Mizuguchi Hiroyuki, Kanehira Makiko, Nishino Naoko, Takahashi Koichi, Mizuno Nobuyasu, Hayakawa Takao, Mayumi Tadanori
Abstract excerpt
Melanoma cells are relatively resistant to adenovirus vector (Ad)-mediated gene transfer due to the low expression of Coxsackie-adenovirus receptor (CAR), which acts as a primitive Ad-receptor. Therefore, extremely high doses of Ad are required for effective gene therapy against melanoma. In the present study, we investigated whether fiber-mutant Ad containing the Arg-Gly-Asp (RGD) sequence in the fiber knob...
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