Article
High gene expression of the mutant adenovirus vector, both in vitro and in vivo, with the insertion of integrin-targeting peptide into the fiber.
Die Pharmazie - 1 Jul 2004
Gao J Q, Inoue S, Tsukada Y, Katayama K, Eto Y, Kurachi S, Mizuguchi H, Hayakawa T, Tsutsumi Y, Mayumi T, Nakagawa S
Abstract excerpt
In the present study, a first-generation adenovirus (Ad) vector was modified with the RGD peptide inserted into the fiber. The insertion of an integrin-targeting sequence into the Ad vector notably enhanced the luciferase expression in the Coxsackie virus and Adenovirus Receptor-deficient A2058 and B16BL6 melanoma cells. The results of an in vivo study with tumor-bearing mice also showed that Ad-RGD-Luc had...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.