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A novel fiber chimeric conditionally replicative adenovirus-Ad5/F35 for tumor therapy

2 Nov 2017

Abstract excerpt

Significant progress has been made in the diagnosis and treatment of cancer; however, significant challenges remain. Conditionally replicating adenoviruses (CRAds), which not only kill cancer cells, but also serve as vectors to express therapeutic genes, are a novel and effective method to treat cancer. However, most adenoviruses are Ad5, which infect cells through the coxsackie and adenovirus receptor (CAR). The...

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PMID: 29144842
DOI: 10.1080/15384047.2017.1395115

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