Article
Imaging chemically modified adenovirus for targeting tumors expressing integrin alphavbeta3 in living mice with mutant herpes simplex virus type 1 thymidine kinase PET reporter gene.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine - 1 Jan 2006
Xiong Zhengming, Cheng Zhen, Zhang Xianzhong, Patel Manish, Wu Joseph C, Gambhir Sanjiv S, Chen Xiaoyuan
Abstract excerpt
UNLABELLED: The aim of this study was to change adenovirus tropism by chemical modification of the fiber knobs with PEGylated RGD peptide for targeting integrin alpha(v)beta(3) that is uniquely or highly expressed in tumor cells and neovasculature of tumors of various origins. METHODS: The first generation Ad (Ad) vector, which expresses the herpes simplex virus type 1 mutant thymidine kinase (HSV1-sr39tk) gene...
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