[Establishment of ACNU-resistant rat gliosarcoma cell lines and their characteristics].

doi:10.2176/nmc.31.846

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Article

[Establishment of ACNU-resistant rat gliosarcoma cell lines and their characteristics].

Neurologia medico-chirurgica - 1 Dec 1991

Saito Y, Hotta T, Mikami T, Kurisu K, Kawamoto K, Kiya K, Uozumi T

Abstract excerpt

One of the most serious problems in cancer chemotherapy is the acquired drug resistance of tumor cells. In order to investigate the mechanism of acquired resistance to 1-(4-amino-2-methyl-5-pyrimidinyl)methyl-3-(2-chloroethyl)-3-nitrosourea hydrochloride (ACNU), nine resistant cells were isolated...

Topics

Animals
Cell Separation
Drug Resistance
Drug Screening Assays, Antitumor
Glioma
Karyotyping
Microscopy, Electron
Mutation
Nimustine
Rats
Tumor Cells, Cultured

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