Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

[Specific curative effects of nitrosourea drugs on tumor cells with Mer--phenotype in Chinese].

Zhongguo yao li xue bao = Acta pharmacologica Sinica - 1 Nov 1993

Zhang Y P, He T, Chen J M, Chen Y N, Xu H Y, Fan G C, Wu Y

Abstract excerpt

O6-Methylguanine DNA methyltransferase (O6-MT) activity and cellular sensitivity to nitrosourea drugs of 10 kinds of tumor cell strains derived from Chinese patients were measured by 3H radioactivity and colony-forming ability, respectively. The results in vitro showed that nimustine (Nim) 25 micrograms.ml-1 and carmustine (Car) 20 micrograms.ml-1 exhibited specific killing effects on Mer-phenotype tumor cells...

Topics

Animals
Carmustine
Female
Humans
Liver Neoplasms
Methyltransferases
Mice
Mice, Inbred BALB C
Mice, Nude
Neoplasm Transplantation
Nimustine
O(6)-Methylguanine-DNA Methyltransferase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Phenotype

Tumor Cells, Cultured

Uterine Cervical Neoplasms

Source

Identifiers

PMID: 8010061

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-8010061-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 9 closest

[Specific curative effects of nitrosourea drugs on tumor cells with Mer--phenotype in Chinese].PMID 8010061Read ↗

Modulation of O6-methylguanine-DNA methyltransferase-mediated 1-(4-amino-2-methyl-5-Pyrimidinyl)- methyl-3-(2-Chloroethyl)-3-nitrosourea resistance by antisense RNA.Semantic proximity Read ↗

[Inhibitory effect of liuwei dihuang decoction on induced mutation and spontaneous tumor].Semantic proximity Read ↗

[Studies on human cervical carcinoma cell line. II. Establishment of HGPRT- cell line CC-80IAR2 and its biological characteristics].Semantic proximity Read ↗

[Effect of bailong recipe on proliferation phenotype of human gastric carcinoma BGC82-3 cell line].Semantic proximity Read ↗

[Establishment of ACNU-resistant rat gliosarcoma cell lines and their characteristics].Semantic proximity Read ↗

[Influence of tumor drug resistance phenotype on the dynamics of cisplatin-induced changes of rat peripheral lymphocyte chromatin structure in Guerin's carcinoma].Semantic proximity Read ↗

[Comparison of TK gene mutation assay in TK6 and TK6-E6 cell induced by vinblastin and colcemid].Semantic proximity Read ↗

Tetrazepinones are equally cytotoxic to Mer+ and Mer- human tumor cell lines.Semantic proximity Read ↗

Differences in induction of sister chromatid exchanges in MNNG-resistant HeLa S3 Mer- cell lines.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.